News article about UTA research: A University of Texas at Arlington bio-analytical chemist exploring proteins, their structures and functions by using cutting-edge analytical instrumentation called mass spectrometry has received an Academic Research Enhancement Award from the National Institutes of Health - See more at: http://www.uta.edu/news/releases/2015/02/chowdhury-protein-research.php#sthash.d8bG2pDe.dpuf
Prenylation of protein (farnesylation and geranylgeranylation) is involved in several human cancers, such as pancreatic, colon, and acute myeloid leukemia as well as Hutchinson-Gilford progeria syndrome (HGPS), a genetic disease that is associated with premature aging for children. Current biochemical methods are not very efficient in identifying and differentiating large-scale prenylations in vivo or in vitro.- See more at: http://pubs.acs.org/doi/abs/10.1021/ac503794s
Toll-like receptor (TLR) signaling networks are crucial as the front line of defense against several microbial and viral pathogens. Upon exposures to viral and bacterial ligands, signaling of TLRs proceeds with two distinct pathways to release inflammatory cytokines;one involves a cytosolic adaptor protein Myeloid differentiation primary response 88 (MyD88) and another requires TRIF.- See more at: http://grantome.com/grant/NIH/UA5-GM113216-01
Lipid raft membrane microdomains organize signaling by many prototypical receptors, including the Toll-like Receptors (TLRs) of the innate immune system. Raft-localization of proteins is widely thought to be regulated by raft cholesterol levels, but this is largely on the basis of studies that have manipulated cell cholesterol using crude and poorly specific chemical tools, such as β-cyclodextrins.- See more at: http://www.ncbi.nlm.nih.gov/pubmed/25910759