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"The Use of Deuterated Camphor as a Substrate in 1H ENDOR Studies of Hydroxylation by Cryoreduced Oxy P450cam Provides New Evidence of the Involvement of Compound I", R. Davydov, J. H. Dawson, R. Perera*, B. M. Hoffman*. Biochemistry, 2013, 52 (4), 667-671. "Biosynthetic Approach for Functional Protein Microarrays", B. Stamos, L. Loredo, S. Chand, T. V. Phan, Y. Zhang, S. Mohapatra, K. Rajeshwar, R. Perera*. Analytical Biochemistry, 2012, 424 (2), 114-123. "Alkylamine-Ligated H93G Myoglobin Cavity Mutant: A Model System for Endogenous Lysine and Terminal Amine Ligation in Heme Proteins such as Nitrite Reductase and Cytochrome f", J. Du, R. Perera, J. H. Dawson. Inorganic Chem., 2011, 50(4), 1242-1249. "Molecular Basis for the Inability of an Oxygen Atom Donor Ligand to Replace the Natural Sulfur Donor Heme Axial Ligand in Cytochrome P450 Catalysis. Spectroscopic Characterization of the Cys436Ser CYP2B4 Mutant." R. Perera, M. Sono, H. L. Voegtle, J. H. Dawson. Archives of Biochemistry and Biophysics, 2011, 507(1), 119-125 "Stabilization and Spectroscopic Characterization of the Dioxygen Complex of Wild-type Cytochrome P450 (CYP) 2B4 and Its Distal Side E301Q, T302A and Proximal Side F429H Mutants at Subzero Temperatures" R. Perera, M. Sono, R. Kinloch, H. Zhang, M. Tarasev, C. Im, L. Waskell, J. H Dawson. Biochimica et Biophysica Acta - Proteins and Proteomics, 2011, 1814(1), 69-75. "Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids", J. Grunewald, G. S. Hunt, L. Dong, F. Niessen, B. G. Wen, M. L. Tsao, R. Perera, M. Kang, B. A. Laffitte, S. Azarian, W. Ruf, M. Nasoff, R. A. Lerner, P. G. Schultz, V. V. Smider. Proc. Natl. Acad. Sci. U.S.A. 2009, 106 (11), 4337-4342. "Immunochemical Termination of Self-Tolerance", J. Grunewald, M. L. Tsao, R. Perera, L. Dong, F. Niessen, B. G. Wen, D. M. Kubitz, V. V. Smider, W. Ruf, M. Nasoff, R. A. Lerner, P. G. Schultz. Proc. Natl. Acad. Sci. U.S.A. 2008, 105 (32), 11276-80. "Selecting Folded Proteins from a Library of Secondary Structural Elements," J. J. Graziano, W. Liu, R. Perera, B. H. Geierstanger, S. A. Lesley, P. G. Schultz. J. Am. Chem. Soc. 2008, 130 (1), 176-185. "A Genetically Encoded Infrared Probe", K. C. Schultz, L. Supekova, Y. Ryu, J. Xie, R. Perera*, P. G. Schultz*. J. Am. Chem. Soc. 2006, 128 (43), 13984-13985. "Rapid Freeze-Quench ENDOR Study of Chloroperoxidase Compound I: The Site of the Radical", S. H. Kim, R. Perera, L. P. Hager, J. H. Dawson, B. M. Hoffman. J. Am. Chem. Soc. 2006, 128 (17), 5598-5599. "Structures of Thiolate- and Carboxylate-Ligated Ferric H93G Myoglobin: Models for Cytochrome P450 and for Oxyanion-Bound Heme Proteins", R. Perera, J. Qin, L. L. Lovelace, J. H. Dawson, L. Lebioda. Biochemistry 2006, 45 (10), 3170-3177. "Subzero-temperature Stabilization and Spectroscopic Characterization of Homogeneous Oxyferrous Complex of the Cytochrome P450 BM3 (CYP 102) Oxygenase Domain and Holoenzyme", R. Perera, M. Sono, G. Raner, J. H. Dawson. Biochem. Biophys. Res. Commun. 2005, 338 (1), 365-371. "The influence of substrate on the spectral properties of oxyferrous Wild-Type and T252A Cytochrome P450-CAM", M. Sono, R. Perera, S. Jin, S. G. Sligar, T. A. Bryson, J. H. Dawson. Arch. Biochem. Biophys. 2005, 436, 40-49. "Substrate Modulation of the Properties and Reactivity of the Oxy-Ferrous and Hydroperoxo-Ferric Intermediates of Cytochrome P450cam as Shown by Cryoreduction-EPR/ENDOR Spectroscopy", R. Davydov, R. Perera, S. Jin, T. C. Yang, T. A. Bryson, M. Sono, J. H. Dawson, B. M. Hoffman. J. Am. Chem. Soc. 2005, 127 (5), 1403-1413. "Cryoreduction EPR and 13C, 19F ENDOR Study of Substrate-Bound Substates and Solvent Kinetic Isotope Effect in the Catalytic Cycle of Cytochrome P450cam and its T252A Mutant", S. H. Kim, T. Yang, R. Perera, S. Jin, T. A. Bryson, M. Sono, R. Davydov, J. H. Dawson, B. M. Hoffman. Dalton Trans. 2005, 21, 3464-3469. "Modeling Heme Protein Active Sites with the His93Gly Cavity Mutant of Sperm Whale Myoglobin: Complexes with Nitrogen-, Oxygen- and Sulfur-Donor Proximal Ligands", R. Perera, J. H. Dawson. J. Porphyrins Phthalocyanines, 2004, 8, 246-254. "EpoK, a Cytochrome P450 Involved in Biosynthesis of the Potential Anticancer Drugs Epothilone A and B. Substrate-Mediated Rescue of a P450 Enzyme", H. Ogura, C. R. Nishida, U. R. Hoch, R. Perera, J. H. Dawson, P. R. Ortiz de Montellano. Biochemistry 2004, 43, 14712-14721. "Spectroscopic Characterization of Five- and Six-Coordinate Ferrous-NO Heme Complexes. Evidence for Heme Fe-Proximal Cysteinate Bond Cleavage in the Ferrous-NO Adducts of the Trp-409Tyr/Phe Proximal Environment Mutants of Neuronal NOS", H. L. Voegtle, M. Sono, S. Adak, A. E. Pond, T. Tomita, R. Perera, D. B. Goodin, M. Ikeda-Saito, D. J. Stuehr, J. H. Dawson. Biochemistry 2003, 42 (8), 2475-2484. "Neutral Thiol as a Proximal Ligand to Ferrous Heme Iron: Implications for Heme Proteins that Lose Cysteine Thiolate Ligation on Reduction," R. Perera, M. Sono, J. A. Sigman, T. D. Pfister, Y. Lu, J. H. Dawson. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3641-3646. Patents; "Protein biochips", R. Perera, B. Stamos, patent pending. "Breaking Immunological Tolerance with a Genetically Encoded Unnatural Amino Acid", J. Grunewald, R. Perera, M. L. Tsao, Lerner, R.A., Schultz, P.G. Patent Application No. PCT/US2009/00813. Book Chapter; "Cytochrome P450-Catalyzed Hydroxylations and Epoxidations", Perera, R.; Jin, S.; Sono, M.; Dawson, J. H. in Metal Ions in Life Sciences, Volume 3: The Ubiquitous Roles of Cytochrome P450 Proteins; A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; John Wiley & Sons Ltd., Chichester, UK; 2007; pp 319-354.
Commentaries & Highlights; Science Editors' Choice, "Embedding a Reporter", Science, 2006, 314, 727 Biophotonics Research, "Scientists genetically encode IR probe", Biophotonics International magazine, December 2006, page 48 Curing Death, "Scientists Find Modified Protein Containing an Unnatural Amino Acid that Breaks Immune Tolerance" Scripps Press Release, "Novel Method Could Aid in Vaccine Development for Cancer and Infectious Diseases" |